Have you run the UDconfig utility on the tablets?
http://forum.bongofish.co.uk/index.php?topic=90.0You can get this to run off a bootable flashdrive pretty easy. Compare the settings of the three tablets that are working to the one that's being flakey. Anything different?
Though now that I think about it Tabletmagic has a lot of the details/settings you can get from udconfig listed under tablet protocol.
Other things you can look at are are the contacts of the serial port clean on the tablet? If you open it up does everything look fine? Broken contacts?
If you're going to much electronics work I highly recommend having a can of something like this around:
http://www.amazon.com/CRC-Industries-05103-Electronic-Cleaner/dp/B000BXOGNI/ref=pd_bbs_sr_2?ie=UTF8&s=automotive&qid=1239030918&sr=8-2 which you can just spray on leads or components, let fully dry (actually does this quickly) and then try again. Other cheaper options are pink erasers and isopropyl alcohol or nail polish remover, you probably have at least some of these in your house already. Only problem with them is you can't easily clean IN the serial port connectors.